Split hospital first in Croatia to use autologous stem cell therapy for jaw joint disorders

(Photo: KBC Split)

KBC Split has achieved a significant milestone in Croatian medicine after successfully performing the country’s first procedure using autologous bone marrow-derived stem cell concentrate in the treatment of degenerative temporomandibular joint (TMJ) conditions.

The procedure was carried out at the Department of Maxillofacial Surgery and represents an important step forward in the field of regenerative medicine within maxillofacial care.

The treatment involved the application of an autologous bone marrow concentrate containing stem cells and other regenerative biological factors. The material was obtained from the patient’s own bone marrow, processed during the procedure, and then applied directly into the affected jaw joint.

As the therapy uses the patient’s own biological material, it is classified as an autologous treatment approach, reducing the risk of rejection and supporting natural tissue regeneration processes.

The concentrate is rich in mesenchymal progenitor cells, which play a key role in tissue repair and regeneration, alongside other bioactive components that may support healing.

The aim of the procedure is to stimulate the regeneration of joint structures and cartilage, reduce pain, and improve jaw function in carefully selected patients.

The procedure was performed by a specialist team from KBC Split’s Department of Maxillofacial Surgery, including Ema Puizina, Danijel Jerković, Dinko Martinović, and Slaven Lupi-Ferandin, with support from operating theatre nursing staff and the anaesthesiology team.

(Photo: KBC Split)

Dr Puizina noted that regenerative medicine is increasingly transforming the treatment of musculoskeletal disorders and is now finding wider application in maxillofacial surgery. She highlighted that the approach aims to harness the body’s natural regenerative capacity in order to preserve joint function, reduce symptoms, and improve patients’ quality of life.

She also emphasised the significance of the achievement, stating that this is the first time the procedure has been performed in Croatia, placing KBC Split among centres offering advanced treatment methods comparable with leading international institutions.

Head of the Department of Maxillofacial Surgery, Saša Ercegović, said the introduction of advanced regenerative therapies reflects the continued development of the department and the hospital’s commitment to modern, evidence-based medical practice.

(Photo: KBC Split)

The procedure marks a notable step in expanding regenerative treatment options for temporomandibular joint disorders in Croatia, with potential implications for future clinical practice in the field.