Croatian startup developing technology to transform biopsy analysis

A Croatian startup based at the Zagreb Innovation Centre (ZICER) is developing a new technology that could significantly speed up the analysis of fresh biopsies, potentially improving cancer diagnostics and patient care.

The solution enables rapid, non-destructive examination of biopsy samples, providing early diagnostic insight without compromising the sample for further laboratory analysis. In modern oncology, where timely and accurate decisions are critical, the technology aims to reduce waiting times that can currently stretch from hours to several days.

The company has spent the past three years developing specialised software designed to streamline the pathological examination process.

Lead software engineer Leo Obadić tells HRT that the system has been built with simplicity in mind to help medical professionals work more efficiently.

The software contains only a few key options, while most technical adjustments are handled automatically. Two neural networks analyse the microscope image and automatically correct brightness, colours and optical imperfections, ensuring high-quality results without requiring manual calibration.

This automation allows clinicians to focus on analysis rather than technical adjustments.

The technology has been created through close cooperation with doctors and researchers. Among the first users is Dr Ivan-Conrado Šoštarić Zuckermann, associate professor at the Department of Veterinary Pathology at the University of Zagreb’s Faculty of Veterinary Medicine.

He explains that the programme simplifies the process of photographing microscopic samples by automating elements such as lighting and colour balance.

In addition, the system uses a mathematical model that can enhance the resolution of certain intracellular structures, enabling more detailed observation during analysis.

Faster Decisions for Doctors and Patients

The software is already being used in several hospitals and scientific institutes across Croatia. Faster sample processing means doctors can make decisions about further treatment much more quickly.

Obadić points to a common scenario in laboratories. Previously, photographing several microscopic slides could take between 20 and 30 minutes. With the new system, the same task can now be completed in just one or two minutes, with most of the remaining time spent simply replacing slides on the microscope.

This reduction in processing time could have a significant impact in clinical settings where speed is crucial.

Growing Interest Beyond Croatia

The innovation has already attracted attention outside Croatia. Institutions in Slovenia and Austria have begun using the technology, recognising the advantages offered by advanced computing algorithms and artificial intelligence working alongside medical professionals.

As interest grows internationally, the Zagreb-developed solution highlights Croatia’s emerging role in health technology innovation, with the potential to contribute to faster and more effective cancer diagnostics worldwide.